Pregabalin Information
Pronunciation
(pre GAB a lin)
What is this drug used for?
– It is used to help control certain kinds of seizures, to treat painful nerve diseases, and to treat fibromyalgia. It may be given to you for other reasons. Talk with the doctor.
Frequently reported side effects of this drug
– Nose irritation
– Throat irritation
– Trouble focusing
– Headache
– Dry mouth
– Loss of strength and energy
– Constipation
– Lack of appetite
– Joint pain
– Nausea
Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:
– Swelling in your throat
– Depression like thoughts of suicide, anxiety, agitation, irritability, panic attacks, mood changes, behavioral changes, or confusion
– Vision changes
– Muscle pain
– Muscle weakness
– Seizures
– Bruising
– Bleeding
– Change in balance
– Confusion
– Tremors
– Trouble breathing
– Slow breathing
– Shallow breathing
– Blue/gray skin discoloration
– Trouble with memory
– Shortness of breath
– Excessive weight gain
– Swelling of arms or legs
– Fast heartbeat
– Abnormal heartbeat
– Chills
– Sore throat
– Skin sores
– Trouble speaking
– Trouble sleeping
– Abnormal gait
– Feeling high
– Twitching
– Severe fatigue
– Severe dizziness
– Passing out
– Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
Medication Safety Issues
Sound-alike/look-alike issues:
Lyrica may be confused with Hydrea, Lopressor
Other safety concerns:
Pregabalin (Lyrica) oral solution (20 mg/mL): Prescriptions should be written in terms of mg. The pharmacist will calculate the appropriate dose in mL for dispensing.
Storage and Stability
Store at 20?C to 25?C (68?F to 77?F); excursions permitted to 15?C to 30?C (59?F to 86?F)
Adverse Reactions
As reported with adult patients, unless otherwise noted.
Cardiovascular: Chest pain, edema, facial edema, hypertension, hypotension, peripheral edema, prolongation P-R interval on ECG
Central nervous system: Abnormal gait, abnormality in thinking, amnesia, anorgasmia, anxiety, ataxia, balance impairment, confusion, depersonalization, disorientation, disturbance in attention, dizziness, drowsiness, euphoria, fatigue, feeling abnormal, headache, hypertonia, hypoesthesia, insomnia, intoxicated feeling, lethargy, memory impairment, myasthenia, nervousness, neuropathy, pain, paresthesia, sedated state, speech disturbance, stupor, twitching (includes myokymia), vertigo
Dermatologic: Contact dermatitis, ecchymoses, pressure ulcer, pruritus
Endocrine & metabolic: Decreased libido, fluid retention, hypoglycemia, weight gain
Gastrointestinal: Abdominal distension, abdominal pain, constipation, diarrhea, flatulence, gastroenteritis, increased appetite, nausea, sialorrhea, viral gastroenteritis, vomiting, xerostomia
Genitourinary: Erectile dysfunction, impotence, urinary frequency, urinary incontinence, urinary tract infection
Hematologic & oncologic: Thrombocytopenia
Hepatic: Increased serum alanine aminotransferase, increased serum aspartate aminotransferase
Hypersensitivity: Hypersensitivity reaction
Infection: Infection, viral infection
Neuromuscular & skeletal: Arthralgia, asthenia, back pain, increased creatine phosphokinase in blood specimen, joint swelling, limb pain, lower limb cramp, muscle spasm, myalgia, neck pain, tremor
Ophthalmic: Blurred vision, conjunctivitis, decreased visual acuity, diplopia, eye disease, nystagmus disorder, visual disturbance, visual field loss
Otic: Otitis media, tinnitus
Respiratory: Bronchitis, cough, dyspnea, flu-like symptoms, nasopharyngitis, pharyngolaryngeal pain, pneumonia, respiratory tract infection, sinusitis
Miscellaneous: Accidental injury, fever
Rare but important or life-threatening: Abnormal dreams, abscess, accommodation disturbance, acute renal failure, ageusia, agitation, albuminuria, alopecia, altered sense of smell, amenorrhea, anemia, angioedema, anisocoria, apathy, aphasia, aphthous stomatitis, apnea, arthropathy, ascites, atelectasis, balanitis, bladder neoplasm, blepharitis, blepharoptosis, blindness, bradykinesia, breast hypertrophy, bronchiolitis, cardiac failure, cellulitis, cerebellar syndrome, cervicitis, chills, cholecystitis, cholelithiasis, chondrodystrophy, cognitive dysfunction, cogwheel rigidity, colitis, coma, corneal ulcer, cutaneous nodule, decreased glucose tolerance, delirium, delusions, depression of ST segment on ECG, dermal ulcer, drug dependence, dry mucous membranes, dysarthria, dysautonomia, dysgeusia, dyskinesia, dysmenorrhea, dyspareunia, dysphagia, dystonia, dysuria, eczema, ejaculatory disorder, encephalopathy, eosinophilia, epididymitis, erythema of skin, esophageal ulcer, esophagitis, exfoliative dermatitis, exophthalmos, extraocular palsy, extrapyramidal reaction, facial pain, gastritis, gastrointestinal hemorrhage, glomerulonephritis, glycosuria, granuloma, Guillain-Barre syndrome, gynecomastia, hallucination, hangover effect, heavy menstrual bleeding, hematuria, hemophthalmos, hiccups, hirsutism, hostility, hypalgesia, hyperacusis, hyperalgesia, hyperesthesia, hyperkinetic muscle activity, hypochromic anemia, hypokinesia, hypoprothrombinemia, hypotonia, impaired consciousness, increased libido, increased neutrophils, increased serum lipase, intracranial hypertension, iritis, irritability, joint stiffness, keratitis, keratoconjunctivitis, lactation (females), laryngismus, leukocytosis, leukopenia, leukorrhea, lichenoid dermatitis, local inflammation (coccydynia), lymphadenopathy, malaise, manic reaction, melanosis, melena, miosis, mydriasis, myelofibrosis, myoclonus, nail disease, neck stiffness, nephritis, nephrolithiasis, neuralgia, nocturnal amblyopia, nonimmune anaphylaxis, nonthrombocytopenic purpura, oliguria, ophthalmoplegia, optic atrophy, oral mucosa ulcer, oral paresthesia, orthostatic hypotension, ovarian disease, palpitations, pancreatitis, papilledema, paranoid ideation, pelvic pain, periodontal abscess, periorbital edema, peripheral neuritis, personality disorder, petechial rash, photophobia, polycythemia, proteinuria, psychomotor disturbance, psychotic depression, pulmonary edema, pulmonary fibrosis, purpuric rash, pustular rash, pyelonephritis, rectal hemorrhage, respiratory depression (FDA Safety Alert, Dec 19, 2019), retinal edema, retinal vascular disease, retroperitoneal fibrosis, rhabdomyolysis, sciatica, schizophrenia, self-inflicted intentional injury, severe thrombocytopenia, shock, skin atrophy, skin blister, skin necrosis, skin photosensitivity, skin rash, sleep disorder, Stevens-Johnson syndrome, subcutaneous nodule, syncope, tachycardia, thrombocythemia, thrombophlebitis, tongue edema, torticollis, trismus, urate crystalluria, urinary retention, urine abnormality, urticaria, uterine hemorrhage, uveitis, ventricular fibrillation, vesiculobullous dermatitis, wheezing, xeroderma, xerophthalmia, yawning
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